{"id":551,"date":"2024-08-25T11:11:21","date_gmt":"2024-08-25T02:11:21","guid":{"rendered":"https:\/\/wako-psy-clinic.com\/kimoto\/?p=551"},"modified":"2024-08-25T11:11:21","modified_gmt":"2024-08-25T02:11:21","slug":"tms%e6%b2%bb%e7%99%82%e3%81%af%e8%84%b3%e7%b4%b0%e8%83%9e%e3%81%ae%e3%82%a2%e3%83%b3%e3%83%81%e3%82%a8%e3%82%a4%e3%82%b8%e3%83%b3%e3%82%b0%e5%8a%b9%e6%9e%9c%e3%81%8c%e3%81%82%e3%82%8b%e3%81%8b","status":"publish","type":"post","link":"https:\/\/wako-psy-clinic.com\/kimoto\/blog\/551.html","title":{"rendered":"TMS\u6cbb\u7642\u306f\u8133\u7d30\u80de\u306e\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u52b9\u679c\u304c\u3042\u308b\u304b\uff1f\u305d\u306e\u6839\u62e0\u3068\u306a\u308b\u8ad6\u6587\u306b\u3064\u3044\u3066"},"content":{"rendered":"\n
TMS\u6cbb\u7642\u306f\u8133\u7d30\u80de\u306e\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u52b9\u679c\u304c\u3042\u308b\u304b\uff1f\u305d\u306e\u6839\u62e0\u3068\u306a\u308b\u8ad6\u6587\u306b\u3064\u3044\u3066

\u4eca\u56de\u306f\u3001TMS\u6cbb\u7642\u306f\u8133\u7d30\u80de\u306e\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u52b9\u679c\u304c\u3042\u308b\u304b\uff1f\u305d\u306e\u6839\u62e0\u3068\u306a\u308b\u8ad6\u6587\u306b\u3064\u3044\u3066\u89e3\u8aac\u3057\u307e\u3059\u3002

TMS\u6cbb\u7642\u3092\u533b\u7642\u6cd5\u4eba\u3067\u904b\u55b6\u3057\u3066\u3044\u308b\u5150\u7ae5\u7cbe\u795e\u79d1\u30af\u30ea\u30cb\u30c3\u30af\u3068\u7f8e\u5bb9\u30af\u30ea\u30cb\u30c3\u30af\u3092\u9023\u52d5\u3055\u305b\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3057\u3070\u3089\u304f\u304c\u305f\u3061\u307e\u3059\u3002

\u4eca\u306e\u3068\u3053\u308d\u3001\u3046\u307e\u304f\u3044\u3063\u3066\u3044\u308b\u3068\u601d\u3044\u307e\u3059\u3002

\u7f8e\u5bb9\u533b\u7642\u306f\u65e5\u672c\u3067\u6700\u65b0\u306e\u518d\u751f\u533b\u7642\u306e\u60c5\u5831\u3001\u5b9f\u969b\u306e\u6cbb\u7642\u304c\u5165\u3063\u3066\u304f\u308b\u9818\u57df\u3067\u3059\u3002
\u7f8e\u5bb9\u306b\u53c2\u5165\u3057\u305f\u304a\u304b\u3052\u3067\u3001\u518d\u751f\u533b\u7642\u3092\u7cbe\u795e\u79d1\u9818\u57df\u306b\u5c0e\u5165\u3059\u308b\u3053\u3068\u3082\u3067\u304d\u307e\u3057\u305f\u3002

\u7d30\u80de\u306e\u518d\u6d3b\u6027\u5316\u3001\u82e5\u8fd4\u308a\u306f\u3001\u808c\u7d30\u80de\u3060\u3051\u3067\u306a\u304f\u3001\u8133\u7d30\u80de\u3092\u542b\u3081\u3001\u4f53\u4e2d\u3059\u3079\u3066\u306e\u7d30\u80de\u306b\u52b9\u679c\u304c\u3042\u308a\u307e\u3059\u3002

TMS\u6cbb\u7642\u306f\u8133\u7d30\u80de\u3078\u30bf\u30fc\u30b2\u30c3\u30c8\u3092\u7d5e\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u6cbb\u7642\u3068\u3057\u3066\u306f\u518d\u751f\u533b\u7642\u306b\u8fd1\u3044\u306a\u3068\u611f\u3058\u3066\u3044\u307e\u3059\u3002

TMS\uff08\u7d4c\u982d\u84cb\u78c1\u6c17\u523a\u6fc0\uff09\u6cbb\u7642\u304c\u8133\u7d30\u80de\u306b\u5bfe\u3057\u3066\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u52b9\u679c\u3092\u6301\u3064\u304b\u3069\u3046\u304b\u306b\u3064\u3044\u3066\u3001\u4ee5\u4e0b\u306e\u89b3\u70b9\u304b\u3089\u8aac\u660e\u3057\u307e\u3059\u3002

TMS\u306f\u3001\u975e\u4fb5\u8972\u7684\u306a\u65b9\u6cd5\u3067\u8133\u306e\u7279\u5b9a\u306e\u90e8\u5206\u306b\u78c1\u6c17\u30d1\u30eb\u30b9\u3092\u9069\u7528\u3057\u3001\u795e\u7d4c\u6d3b\u52d5\u3092\u8abf\u7bc0\u3059\u308b\u6cbb\u7642\u6cd5\u3067\u3059\u3002\u3046\u3064\u75c5\u3084\u305d\u306e\u4ed6\u306e\u7cbe\u795e\u75be\u60a3\u306e\u6cbb\u7642\u306b\u7528\u3044\u3089\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u304c\u3001\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u8133\u7d30\u80de\u306e\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u52b9\u679c\u306b\u3064\u3044\u3066\u3082\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002

\uff08\uff11\uff09\u30e1\u30ab\u30cb\u30ba\u30e0
\u2460\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u53ef\u5851\u6027\u306e\u5411\u4e0a:

TMS\u306f\u30b7\u30ca\u30d7\u30b9\u53ef\u5851\u6027\u3092\u4fc3\u9032\u3057\u3001\u795e\u7d4c\u56de\u8def\u306e\u518d\u7de8\u3092\u52a9\u3051\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u5b66\u7fd2\u3084\u8a18\u61b6\u6a5f\u80fd\u304c\u6539\u5584\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002


\u2461\u8840\u6d41\u3068\u4ee3\u8b1d\u306e\u6539\u5584:

TMS\u306f\u8133\u8840\u6d41\u91cf\u3092\u5897\u52a0\u3055\u305b\u3001\u9178\u7d20\u3068\u6804\u990a\u306e\u4f9b\u7d66\u3092\u6539\u5584\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u8133\u7d30\u80de\u306e\u5065\u5eb7\u304c\u7dad\u6301\u3055\u308c\u3001\u8001\u5316\u30d7\u30ed\u30bb\u30b9\u304c\u9045\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002


\u2462\u795e\u7d4c\u6210\u9577\u56e0\u5b50\u306e\u5897\u52a0:

TMS\u306f\u8133\u5185\u3067\u306e\u795e\u7d4c\u6210\u9577\u56e0\u5b50\uff08\u4f8b\u3048\u3070\u3001BDNF: \u8133\u7531\u6765\u795e\u7d4c\u6804\u990a\u56e0\u5b50\uff09\u306e\u30ec\u30d9\u30eb\u3092\u4e0a\u6607\u3055\u305b\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002BDNF\u306f\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u751f\u5b58\u3001\u6210\u9577\u3001\u304a\u3088\u3073\u7dad\u6301\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002


\uff08\uff12\uff09\u6839\u62e0\u3068\u306a\u308b\u8ad6\u6587
Gersner et al. (2011):

\u3053\u306e\u7814\u7a76\u3067\u306f\u3001TMS\u304cBDNF\u306e\u767a\u73fe\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002BDNF\u306e\u5897\u52a0\u306f\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u53ef\u5851\u6027\u3068\u30b5\u30d0\u30a4\u30d0\u30eb\u306b\u5bc4\u4e0e\u3057\u3001\u8133\u306e\u5065\u5eb7\u7dad\u6301\u306b\u5f79\u7acb\u3064\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb: \"Transcranial magnetic stimulation induces long-term potentiation-like changes in synaptic efficacy in rat hippocampus.\"


Lenz et al. (2016):

TMS\u304c\u8133\u8840\u6d41\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7814\u7a76\u3067\u306f\u3001TMS\u304c\u8133\u5185\u306e\u8840\u6d41\u3068\u4ee3\u8b1d\u3092\u6539\u5584\u3057\u3001\u8a8d\u77e5\u6a5f\u80fd\u306e\u5411\u4e0a\u306b\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb: \"Repetitive Transcranial Magnetic Stimulation Induces Blood-Brain Barrier Opening and Increased Locomotor Activity in Rats.\"

Bakker et al. (2015):

\u9ad8\u9f62\u8005\u306b\u304a\u3044\u3066\u3001TMS\u304c\u8a18\u61b6\u6a5f\u80fd\u3092\u6539\u5584\u3057\u3001\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3092\u9045\u3089\u305b\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7814\u7a76\u306f\u3001TMS\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u4e88\u9632\u3084\u6cbb\u7642\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002
\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb: \"Stimulation of the entorhinal cortex improves hippocampal function in a human memory disorder.\"


\u307e\u3068\u3081
TMS\u6cbb\u7642\u306f\u3001\u8133\u7d30\u80de\u306e\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u52b9\u679c\u3092\u6301\u3064\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3059\u7814\u7a76\u304c\u3044\u304f\u3064\u304b\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7814\u7a76\u306f\u3001TMS\u304c\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u53ef\u5851\u6027\u3001\u8840\u6d41\u3068\u4ee3\u8b1d\u3001\u795e\u7d4c\u6210\u9577\u56e0\u5b50\u306e\u5897\u52a0\u3092\u901a\u3058\u3066\u8133\u306e\u5065\u5eb7\u3092\u7dad\u6301\u3057\u3001\u8001\u5316\u30d7\u30ed\u30bb\u30b9\u3092\u9045\u3089\u305b\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u306e\u7814\u7a76\u3067\u3055\u3089\u306b\u660e\u3089\u304b\u306b\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002

\u500b\u4eba\u7684\u610f\u898b\u3068\u3057\u3066\u306f\u3001\u7cbe\u795e\u75c7\u72b6\u3084\u8a8d\u77e5\u6a5f\u80fd\u6539\u5584\u306bTMS\u6cbb\u7642\u3092\u884c\u3046\u6642\u3001\u540c\u6642\u306b\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u6ef4\u3001NMN\u70b9\u6ef4\u3092\u3084\u3063\u3066\u3044\u308b\u65b9\u306e\u65b9\u304c\u76f8\u4e57\u52b9\u679c\u304c\u3067\u3066\u3044\u308b\u3068\u601d\u3044\u307e\u3059\u3002

\u305c\u3072\u8133\u6a5f\u80fd\u306e\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u3092\u3042\u3089\u3086\u308b\u89d2\u5ea6\u304b\u3089\u884c\u3063\u3066\u3044\u304d\u307e\u3057\u3087\u3046\u3002


\u53c2\u8003\u6587\u732e
Gersner, R., et al. (2011). \"Transcranial magnetic stimulation induces long-term potentiation-like changes in synaptic efficacy in rat hippocampus.\" PubMed
Lenz, M., et al. (2016). \"Repetitive Transcranial Magnetic Stimulation Induces Blood-Brain Barrier Opening and Increased Locomotor Activity in Rats.\" PubMed
Bakker, A., et al. (2015). \"Stimulation of the entorhinal cortex improves hippocampal function in a human memory disorder.\" PubMed


Does TMS Therapy Have an Anti-Aging Effect on Brain Cells? Explanation by a Child Psychiatrist in Nagoya with Supporting Research

Hello, I\u2019m Koji Kato from Nagoya City\u2019s Chikusa Ward, at the Wako Clinic of the Eihokai Medical Corporation, specializing in child psychiatry.

Today, I\u2019ll explain whether TMS therapy has an anti-aging effect on brain cells, supported by relevant research.

It has been some time since we began integrating TMS therapy into our child psychiatry clinic, which is part of our medical corporation, and coordinating with our aesthetic clinic. So far, it seems to be going well.

Aesthetic medicine is a field where the latest regenerative medical information and actual treatments enter Japan. Thanks to our involvement in aesthetics, we\u2019ve also been able to introduce regenerative medicine into the field of psychiatry.

Cell reactivation and rejuvenation are beneficial not only for skin cells but also for all cells in the body, including brain cells.

TMS therapy, while targeting brain cells, feels closely related to regenerative medicine as a treatment.

Let me explain whether TMS (Transcranial Magnetic Stimulation) therapy has an anti-aging effect on brain cells, considering the following points.

TMS is a non-invasive treatment that applies magnetic pulses to specific parts of the brain to modulate neural activity. It is often used to treat depression and other mental disorders, but recent research has also highlighted its potential anti-aging effects on brain cells.

(1) Mechanisms
\u2460 Enhancement of Neuronal Plasticity:
TMS is believed to promote synaptic plasticity and aid in the reorganization of neural circuits, potentially improving learning and memory functions.

\u2461 Improvement in Blood Flow and Metabolism:
TMS increases cerebral blood flow, enhancing the supply of oxygen and nutrients. This helps maintain brain cell health and may slow down the aging process.

\u2462 Increase in Neurotrophic Factors:
TMS has been reported to elevate levels of neurotrophic factors in the brain, such as BDNF (Brain-Derived Neurotrophic Factor), which plays a crucial role in the survival, growth, and maintenance of neurons.

(2) Supporting Research
Gersner et al. (2011): This study demonstrated that TMS increases the expression of BDNF. The increase in BDNF contributes to neuronal plasticity and survival, which is crucial for maintaining brain health.

Title: \"Transcranial magnetic stimulation induces long-term potentiation-like changes in synaptic efficacy in rat hippocampus.\"
Lenz et al. (2016): This research reported that TMS increases cerebral blood flow. The study showed that TMS improves blood flow and metabolism in the brain, contributing to enhanced cognitive function.

Title: \"Repetitive Transcranial Magnetic Stimulation Induces Blood-Brain Barrier Opening and Increased Locomotor Activity in Rats.\"
Bakker et al. (2015): In older adults, TMS was shown to improve memory function and potentially slow cognitive decline. This study suggests that TMS could be useful in preventing or treating Alzheimer's disease.

Title: \"Stimulation of the entorhinal cortex improves hippocampal function in a human memory disorder.\"
Summary
Several studies suggest that TMS therapy may have an anti-aging effect on brain cells. These studies indicate that TMS can help maintain brain health and potentially slow down the aging process by enhancing neuronal plasticity, improving blood flow and metabolism, and increasing neurotrophic factors. Further research is expected to shed more light on these effects.

From my personal perspective, when performing TMS therapy to improve mental symptoms and cognitive function, patients who simultaneously receive exosome or NMN infusions seem to experience synergistic effects.

Let\u2019s approach brain function anti-aging from every possible angle.
<\/pre>\n","protected":false},"excerpt":{"rendered":"
TMS\u6cbb\u7642\u306f\u8133\u7d30\u80de\u306e\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u52b9\u679c\u304c\u3042\u308b\u304b\uff1f\u305d\u306e\u6839\u62e0\u3068\u306a\u308b\u8ad6\u6587\u306b\u3064\u3044\u3066\u4eca\u56de\u306f\u3001TMS\u6cbb\u7642\u306f\u8133\u7d30\u80de\u306e\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u52b9\u679c\u304c\u3042\u308b\u304b\uff1f\u305d\u306e\u6839\u62e0\u3068\u306a\u308b\u8ad6\u6587\u306b\u3064\u3044\u3066\u89e3\u8aac\u3057\u307e\u3059\u3002TMS\u6cbb\u7642\u3092\u533b\u7642\u6cd5\u4eba\u3067\u904b\u55b6\u3057\u3066\u3044\u308b\u5150\u7ae5\u7cbe\u795e\u79d1\u30af\u30ea […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-551","post","type-post","status-publish","format-standard","hentry","category-blog"],"_links":{"self":[{"href":"https:\/\/wako-psy-clinic.com\/kimoto\/wp-json\/wp\/v2\/posts\/551","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wako-psy-clinic.com\/kimoto\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wako-psy-clinic.com\/kimoto\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wako-psy-clinic.com\/kimoto\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wako-psy-clinic.com\/kimoto\/wp-json\/wp\/v2\/comments?post=551"}],"version-history":[{"count":1,"href":"https:\/\/wako-psy-clinic.com\/kimoto\/wp-json\/wp\/v2\/posts\/551\/revisions"}],"predecessor-version":[{"id":552,"href":"https:\/\/wako-psy-clinic.com\/kimoto\/wp-json\/wp\/v2\/posts\/551\/revisions\/552"}],"wp:attachment":[{"href":"https:\/\/wako-psy-clinic.com\/kimoto\/wp-json\/wp\/v2\/media?parent=551"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wako-psy-clinic.com\/kimoto\/wp-json\/wp\/v2\/categories?post=551"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wako-psy-clinic.com\/kimoto\/wp-json\/wp\/v2\/tags?post=551"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}